Alendronate drug interactions

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Contents 1 Drug-drug interactions 2 Drug-food/drug-herb interactions 3 References

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Drug-drug interactions

Severity level	Drug and description of interaction
4	None known
3	aspirin, nonsteroidal antiinflammatory drugs (NSAIDs): The risk of upper GI side effects is increased when co-administered with ASA or NSAIDs.[1]
2	H2-blockers, proton pump inhibitors: The risk of upper GI side effects is increased when co-administered with H2-blockers or PPIs by affecting the bioavailability of alendronate.[1] loop diuretics: The risk of hypocalcemia is increased when IV alendronate is co-administered with loop diuretics.[2][3] aluminum hydroxide, antacids, calcium carbonate, calcium salts, iron salts, magnesium salts, polysaccharide-iron complex: The absorption of alendronate is decreased when co-administered with metal cations.[1]
1	teriparatide: The anabolic activity of teriparatide is decreased when it is co-administered with alendronate.[4][5]

Drug-food/drug-herb interactions

Severity level	Drug and description of interaction
4	None known
3	food: The bioavailability of alendronate is decreased when co-administered with food.[1]
2	None known
1	None known

References

1. ↑ ^{1.0 1.1 1.2 1.3}
2. ↑ Zometa® (zoledronic acid) package insert. East Hanover, NJ: Novartis Pharma Stein AG;2004 Mar.
3. ↑ Lasix® (furosemide) package insert. Bridgewater, NJ: Aventis Pharmaceuticals; 2004 Jan.
4. ↑ Black DM, Greenspan SL, Ensrud KE, et al. The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N Engl J Med 2003;349:1207—15.
5. ↑ Finkelstein JS, Hayes A, Hunzelman JL, et al. The effects of parathyroid hormone, alendronate or both in men with osteoporosis. N Engl J Med 2003;349:1216—26.