Cholecalciferol Drug Interactions

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Note: Cholecalciferol is a weak inhibitor of CYP2C9, 2C19 and 2D6.

Contents 1 Increased Effect/Toxicity 2 Decreased Effect 3 Drug/Herb Interactions 4 References

Increased Effect/Toxicity

• Magaldrate, magnesium hydroxide and magnesium citrate: The concentration of magnesium may be increased by vitamin D analogs when cholecalciferol is co-administered with magnsium-containing drugs.^[1][2]
• Phosphorus Salts and vitamin D analog: The risk of hyperphosphatemia increased by vitamin D analogs when cholecalciferol is co-administered with them.^[1][2]
• Corticosteroids: Corticosteroids decrease the absorption of calcium, which opposes the effect of cholecalciferol.^[3]

Decreased Effect

• Thiazide diuretics, barbiturates, phenytoin and fosphenytoin: The metabolism of cholecalciferol is increased when cholecalciferol is co-administered with these drugs.^[4]
• Cholestyramine, colestipol, mineral oil and orlistat: The absorption of vitamin D is reduced when cholecalciferol is co-administered with these drugs.^[5][6][7][8]
• Food: The abosorption of cholecalciferol is decreased when co-administered with certain foods eg. olestra.^[9]

Drug/Herb Interactions

• None Known

References

1. ↑ ^1.0 1.1 Rocaltrol® (calcitriol) package insert. Nutley, NJ: Roche Laboratories, Inc.; 2004 Jul.
2. ↑ ^2.0 2.1 Hectorol® (doxercalciferol) package insert. Middleton, WI: Bone Care International, Inc.; 2005 Jun.
3. ↑ Amin S, LaValley MP, Simms RW, et al. The role of vitamin D in corticosteroid-induced osteoporosis: an analytical approach. Arthritis Rheum 1999;42:1740—51.
4. ↑ McNamara JO. Drugs effective in the therapy of the epilepsies.Gilman AG, Hardman JG, Limbird LE, (eds.) In: Goodman and Gilman's The Pharmacological Basis of Therapeutics. 10th ed., New York, McGraw-Hill Companies. 2001:530—2.
5. ↑ Questran® and Questran® Light (cholestyramine) package insert. Spring Valley, NY: Par Pharmaceutical Inc; 2002 July.
6. ↑ Colestid® and Flavored Colestid® (colestipol) package insert. Kalamazoo, MI: Pharmacia & Upjohn Company; 2002 July.
7. ↑ Drisdol® (ergocalciferol) package insert. New York, NY: Sanofi-Synthelabo, Inc.; 2003 Dec.
8. ↑ Xenical® (orlistat) package insert. Nutley, NJ: Roche Laboratories Inc.; 2005 Jan.
9. ↑ Lexi-Comp (2003). Drug Information Handbook. 11th Edition., APhA.

Cholecalciferol