Famciclovir Drug Interactions

From Pubdrug

Non-certified Authored by: Lap22 08:48, 16 April 2007 (PDT)

You are reading a non-certified PubDrug document. This document is incomplete and not ready for final editing, review, and certification. Until this document is certified, any registered PubDrug user may edit its content.

Contents 1 Famciclovir Drug Interactions 2 Increase concentration or Toxic Effect: Level Two 3 Increase concentration or Toxic Effect: Level One 4 References

Famciclovir Drug Interactions

Increase concentration or Toxic Effect: Level Two

Probenecid: Studies have shown an increase in acyclovir AUC and peak serum concentration after administration of famciclovir and probenecid. The effects of this interaction are unknown and there are currently no dose adjustments recommended. ^[1]

Back to top

Increase concentration or Toxic Effect: Level One

Digoxin: Studies have shown an increase of up to 19% in digoxin Cmax when these two drugs are used concomitantly. This interaction does not appear to be clinically significant.^[2]

Back to top

Back to Famciclovir

References

1. ↑ Famvir® (famciclovir) package insert. East Hanover, NJ: Novartis Pharmaceuticals Corp.; 2004 Mar
2. ↑ Pue MA, Saporito M, Laroche J, et al. An investigation of the potential interaction between digoxin and oral famciclovir in healthy male volunteers. Br J Clin Pharmacol 1993;36:177P.