Glipizide drug interactions

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Contents 1 Drug-drug interactions 2 Drug-food/drug-herb interactions 3 References	This page is not completed and has not been reviewed for accuracy. You are reading a non-certified PubDrug document. This document is incomplete and not ready for final editing, review, and certification. Until this document is certified, any registered PubDrug user may edit its content. Authored by: Frahman 14:51, 18 November 2007 (PST) Certified by: certifier signature (four tildes)
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Drug-drug interactions

Severity level	Drug and description of interaction
4	Gatifloxacin:Gatifloxacin can cause either hypoglycemia or hyperglycemia when taken with glipizide.[1]
3	Methotrexate:Methotrexate, is partally bound to plsma proteins. Drugs such as glipizide can displace it and cause methotrexate.[2]
2	Ace Inhibitors:Ace inhibitors can cause hypoglycemia.[3] Beta blockers:Beta blockers masks the symptoms of hypoglycemia. .[4] Reserpine:Reserpine blocks the symptoms of hypoglycemia. [5] H2 blockers:H2blockers can cause hyploglycemia by decreasing the clearance of glipizide. [6] Atypical Antipsychotics:Atypical Antipsychotics can cause hyperglycemia and diabetic ketoacidosis because they can induce insulin resistance.[7] Fibric acid derivatives:Fibric acid derivatives can enhance the effect of glipizide, resulting in increased risk of hypoglycemia.[8] Cyclosporine:Glipizide increases cyclosporine concentrations in the blood.[9] Azoles:Asoles can cause hypoglycemia.[10] Metoclopramide:Metoclopramide enhances gastric emptying resuting in dose adjustment of glipizide.[11] Salicylates:Salicylates can cause hypoglycemia.[12] Tetracycline:Tetracycline can cause additive photosensativity reaction when given with glipizide.[13] Thiazide Diuretics:Thiazide Diuretics can increse blood glucose levels.[14] Sulindac:Sulindac can cause hypoglycemia. [15]
1	Baclofen:Giving baclofen with glipizide can increse blood glucose levels.[16] Furosemide,Torsemide,Bumetanide:Giving loop diuretics with glipizide can cause hyperglycemia.[17] Estrogen,Oral contraceptives: Estrogen and oral contraceptives can impair glucose tolerance, resulting in elevated glucose levels.[18] Isoniazid: Isoniazid can increse glucose levels.[19] Phenytoin,Fosphenytoin: phenytoin and fosphenytoin has the potential to increase blood glucose.[20] Triamterene:Triamterene can increase blood glucose level.[21]

Drug-food/drug-herb interactions

Severity level	Drug and description of interaction
4	None known
3	None known
2	Green Tea:Green Tea can decrease plasma glucose levels.[22] Vitamin E:Vitamin can potentiate the effect of glipizide which can result in hypoglycemia.[23]
1	L-carnitine,chromium : Both of these supplements can potentially cause hypoglycemia if giving with glipizide.[24] Aloe vera, Bilberry,Burdock,Bitter Melon,Cornsilk,Eucalyptus,Fenugreek,Panax Ginseng, Marshmallow,Myrrh: All these supplements can cause hypoglycemia when given with glipizide.[25]

References

1. ↑ Biggs.W.Hypoglycemia and Hyperglycemia Associated with Gatifloxacin Use in Elderly Patients The Journal of the American Board of Family Practice 16:455-457 (2003).
2. ↑ Rheumatrex (methotrexate) package insert. Cranbury, NJ: STADA Pharmaceuticals, Inc.; 2003).
3. ↑ Klaus R, Sabine F.Enhancement of blood glucose lowering effect of a sulfonylurea when coadministered with an ACE inhibitor: results of a glucose. Diabetes/Metabolism Research and Reviews 21:5 459-464 2005).
4. ↑ http://www.unckidneycenter.org/patients/drug_info/beta.html).
5. ↑ Glucotrol [package insert]. New York, NY: Pfizer Inc.; October 2007.
6. ↑ Glucotrol [package insert]. New York, NY: Pfizer Inc.; October 2007.
7. ↑ Luna B, Feinglos MN. Drug-induced hyperglycemia. JAMA 286:1945-1948 2001.
8. ↑ Pandit MK, Burke J, Gustafson AB, et al. Drug-induced disorders of glucose tolerance. Annals of Internal Medicine 118:529-539 1993.
9. ↑ (glucotrol package insert)New York, NY: Pfizer Inc.; October 2007.
10. ↑ Glucotrol [package insert]. New York, NY: Pfizer Inc.; October 2007.
11. ↑ Reglan (metoclopramide) package insert. Milwaukee, WI: Schwarz Pharma; 2004.
12. ↑ Gilbert RE, Cooper ME, Krum H. Drug Administration in Patients with Diabetes Mellitus, Safety Considerations. Drug Safety 18:441-455 1998.
13. ↑ Moore DE. Drug-induced cutaneous photosensitivity: incidence, mechanism, prevention and management. Drug Safety 25:345-372 2002.
14. ↑ Dyrenium(triamterene) package insert. Neptune, NJ: Wellspring Pharmaceuticals; 2001.
15. ↑ Glucotrol [package insert]. New York, NY: Pfizer Inc.; October 2007.
16. ↑ Pandit MK, Burke J, Gustafson AB, et al. Drug-induced disorders of glucose tolerance. Annals of Internal Medicine 118:529-539 1993.
17. ↑ Glucotrol [package insert]. New York, NY: Pfizer Inc.; October 2007.
18. ↑ http://www.fda.gov/cder/guidance.
19. ↑ Luntz GRWN, Smith SG. Effect of isoniazid on carbohydrate metabolism in controls and diabetics. BMJ 1:296-299.
20. ↑ Carter BL, Small RE, Mandel MD et al. Phenytoin-induced hyperglycemia. Am J Hosp Pharm 38:1508-1512 1981.
21. ↑ Dyrenium(triamterene) package insert. Neptune, NJ: Wellspring Pharmaceuticals; 2001 Jun.
22. ↑ Shimizu M, Kobayashi Y, Suzuki M, et al. Regulation of intestinal glucose transport by tea catechins. Biofactors 13:61-65 2000.
23. ↑ Paolisso G, D'Amore A, Giugliano D, et al. Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin-dependent diabetic patients. Am J Clin Nutr 57:650-656, 1993.
24. ↑ Mingrone G. L-carnitine improves glucose disposal in type 2 diabetic patients. J Am Col Nutr 18: 77-82, 1999.
25. ↑ Newall CA, Anderson LA, Phillipson JD. Herbal Medicines A Guide for Health-care Professionals. London: The Pharmaceutical Press, 1996.