Latanoprost drug interactions

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Drug-drug interactions

Severity levelClick here to see Severity Level Legend Drug and description of interaction
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3 more than one topical ophthalmic drug: Decreased efficacy of either the other ophthalmic drug or Xalatan may result. If more than one topical ophthalmic drug is being used; ie Xalatan and another topical ophthalmic drug, then separate the administration of the topical ophthalmic drugs by at least five (5) minutes apart from each other.[1]

more than one topical prostaglandin analogue: Decreased efficacy of Xalatan and the other prostaglandin analogue drug may result. The manufacturer recommends that only one prostaglandin analogue should be used once daily, as two prostaglandin analogue drugs may result in a decrease of the intraocular pressure lowering effect of prostaglandin analogues, as well as a paradoxical elevation in intraocular pressure.[1]
topical ophthalmic drug, ie eyedrops, containing thimerosal: Xalatan and thimerosal containing eyedrops may cause precipitation when both drugs are used concomitantly. If Xalatan is used comcomitantly with eyedrops containing thimerosal, then separate the administration of the topical ophthalmic drugs by at least five (5) minutes apart from each other. [1]
topical pilocarpine eyedrops: Xalatan and pilocarpine eyedrops can have an additive effect on decreasing the intraocular pressure in glaucoma or ocular hypertension. Maximum intraocular pressure reduction occurs when pilocarpine is instilled four times daily, and when the bedtime dose of pilocarpine is instilled one (1) hour after instilling latanoprost. [2]

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References

  1. ↑ 1.0 1.1 1.2 Xalatan® (latanoprost) package insert. New York City, NY; Pfizer, Inc./Cardinal Health; 2006 November.
  2. ↑ Kent AR, Vroman DT, Thomas TJ, Hebert RL, Crosson CE. Interaction of pilocarpine with latanoprost in patients with glaucoma and ocular hypertension. Journal of Glaucoma. 1999;8(4):257-262.
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