Pregabalin drug interactions

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Contents 1 Drug-drug interactions 2 Drug-food/drug-herb interactions 3 References

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Drug-drug interactions

Severity level	Drug and description of interaction
4	None known
3	None known
2	barbiturates, benzodiazepines, buprenorphine, butorphanol, dronabinol, entacapone, general anesthetics, nabilone, nalbuphine, opiate agonists, pentazocine, phenothiazines, sedating H1-blockers, tolcapone, tramadol, tricyclic antidepressants (TCAs): increased risk for CNS depression; specifically sedation.[1][2][3][4][5][6][7][8] pioglitazone, rosiglitazone: when thiazolidinediones and pregabalin were taken concomitantly, there was an increased likelihood of weight gain and peripheral edema. Peripheral edema was reported in 3% of patients taking thiazolidinediones, 8% of patients taking pregabalin and 19% of patients taking pregabalin and thiazolidinediones together. Weight gain was reported in 0% of patients taking thiazolidinediones, 4% of patients taking pregabalin and 7.5% of patients taking thiazolidinediones and pregabalin. Weight gain and edema can increase heart failure symptoms.[9]
1	None known

Drug-food/drug-herb interactions

Severity level	Drug and description of interaction
4	None known
3	None known
2	ethanol: increased risk for CNS depression; specifically sedation.[6]
1	None known

References

1. ↑ Forde G. Adjuvant analgesics for the treatment of neuropathic pain: Evaluating efficacy and safety profiles. The Journal of family practice. 2007 Feb;56(2):3-12.
2. ↑ Pande AC, Crockatt JG, Feltner DE, Janney CA, Smith WT, Weisler R, et al. Pregabalin in generalized anxiety disorder: a placebo-controlled trial. The American journal of psychiatry. 2003 Mar;160(3):533-40.
3. ↑ Davis MP. What is new in neuropathic pain? Support Care Cancer. 2006 Nov 28.
4. ↑ Micromedex. Butorphanol (Nasal-Systemic). MayoClinic.com,; 1998.
5. ↑ Cesamet™ (nabilone) package insert. Costa Mesa, CA: Valeant Pharmaceuticals International; 2006.
6. ↑ ^6.0 6.1 Frampton JE, Foster RH. Pregabalin: in the treatment of postherpetic neuralgia. Drugs. 2005;65(1):111-8; discussion 9-20.
7. ↑ American society of Health-System Pharmacists Inc. Nalbuphine Injection. MedLine plus; 2003.
8. ↑ American society of Health-System Pharmacists Inc. Pentazocine and Naloxone. MedLine Plus; 2003.
9. ↑ Pfizer Inc. Pregabalin (Lyrica) package insert. In: Distributed by Parke-Davis, editor. New York, NY: Pfizer; 2006.