Rosiglitazone drug interactions

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Drug-drug interactions

Severity levelClick here to see Severity Level Legend Drug and description of interaction
4 gatifloxacin: a quinolone is contraindicated for use with antidiabetic agents. Serious alterations in blood glucose have been reported. [1]
3 None known
2 gemfibrozil, montelukast: Rosiglitazone is a CYP 2C8 substrate therefore administration with gemfibrozil or montelukast CYP 2C8 inhibitors may lead to higher rosiglitazone concentrations and side effects. [2] [3]

ketoconazole, fluconazole, miconazole, and voriconazole CYP 2C9 inhibitors may cause an increase in therapeutic effect or adverse effects of rosiglitazone. [4][5]

1 rifampin: a CYP 2C8 Inducer was found to decrease the mean AUC for rosiglitazone by 66% and the mean elimination half-life from 3.9 to 1.5 hours. Therefore a decreased rosiglitazone efficacy may be seen. [6]

Drug-food/drug-herb interactions

Severity levelClick here to see Severity Level Legend Drug and description of interaction
4 None known
3 None known
2 Green Tea: catechins shown to decrease serum glucose concentrations thus increased risk for hypoglycemia. [7]
1 Ethanol: A single administration of a moderate amount of alcohol did not increase the risk of acute hypoglycemia but ethanol may cause variable effects on glycemic control. Blood glucose should be monitored closely and dosage adjustment made if necessary. [2]

References

  1. ↑ Tequin® (gatifloxacin) package insert. Princeton, NJ: Bristol-Myers Squibb Company; 2006 Jan.
  2. ↑ 2.0 2.1 Avandia®(Rosiglitazone maleate) package insert,Research Triangle Park, NC; GlaxoSmithKline:2007 http://us.gsk.com/products/assets/us_avandia.pdf
  3. ↑ Singulair® (montelukast) package insert. Whitehouse Station, NJ: Merck & Co, Inc.; 2006 Jun.
  4. ↑ Park J, Kim K, Shin J, et al. Effect of ketoconazole on the pharmacokinetics of rosiglitazone in healthy subjects. Br J Clin Pharmacol 2004;58:397—402.
  5. ↑ Hansten PD, Horn JR. Cytochrome P450 Enzymes and Drug Interactions, Table of Cytochrome P450 Substrates, Inhibitors, Inducers and P-glycoprotein, withFootnotes. In: The Top 100 Drug Interactions - A guide to Patient Management. 2007 Edition. Freeland, WA: H&H Publications; 2007:159—175.
  6. ↑ Park JY, Kim KA, Kang MH, et al. Effect of rifampin on the pharmacokinetics of rosiglitazone in healthy subjects. Clin Pharmacol Ther 2004;75:157—62.
  7. ↑ Shimizu M, Kobayashi Y, Suzuki M, et al. Regulation of intestinal glucose transport by tea catechins. Biofactors 2000;13:61—5.
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