Valacyclovir drug interactions

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Drug-drug interactions

Severity levelClick here to see Severity Level Legend Drug and description of interaction
4 None known
3 None known
2 entecavir: Due to the fact that entecavir is primarily eliminated by the kidneys and valacyclovir has a potential to affect renal function, concurrent administration of these two drugs may increase the serum concentrations of entecavir and the frequency of associated adverse events. The manufacturer of entecavir recommends monitoring for adverse effects when these drugs are administered concurrently.[1]

probenecid: Studies have shown an increase in acyclovir AUC and peak serum concentration after administration of valacyclovir and probenecid. The effects of this interaction are unknown and there are currently no dose adjustments recommended.[2]

tenofovir: Due to competition for renal tubular secretion by valacyclovir and tenofovir, increases in serum concentrations of tenofovir are possible when these two medications are given concurrently.[3]

1 cimetidine: Studies have shown an increase in acyclovir AUC and peak serum concentration after administration of valacyclovir and cimetidine. The effects of this interaction are unknown and there are currently no dose adjustments recommended.[2]

fosphenytoin/phenytoin: It was documented in a case report that when acyclovir was added to an anti-seizure regimen that consisted of phenytoin and valproate, serum phenytoin concentrations were significantly decreased and seizure control was lost. The phenytoin dose was adjusted in order to regain control of the seizures.[4]

Drug-food/drug-herb interactions

Severity levelClick here to see Severity Level Legend Drug and description of interaction
4 None known
3 None known
2 None known
1 None known


References

  1. ↑ Baraclude™ (entecavir) package insert. Princeton, NJ: Bristol-Myers Squibb Company; 2005 Mar.
  2. ↑ 2.0 2.1 DeBony F, Tod M, Bidault M, et al. Multiple interactions of cimetidine and probenecid with valacyclovir and its metabolite acyclovir. Antimicrob Agents Chemother 2002;46:458—63.
  3. ↑ Viread® (tenofovir) package insert. Foster City, CA: Gilead; 2006 May.
  4. ↑ Parmeggiani A, Riva R, Posar A, et al. Possible interaction between acyclovir and antiepileptic treatment. Ther Drug Monit 1995;17:312—5.
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